Tag: gene silencing

Antisense oligonucleotides (ASOs; sometimes abbreviated as AONs) are a form of gene silencing discovered in 1978. The first ASO drug was approved by the FDA 20 years later in 1998. Another form of gene silencing is RNA interference (RNAi) and was discovered in 1998. The first RNAi drug was approved by the FDA 20 years…